PERSONAL PROFILE

Professor Prendergast joined Guys and St Thomas’ Trust in March 2015 as Co-director of the Cardiac Structural Intervention Programme. Before recruitment to London, he trained in Cardiology in Cardiff, Paris and Edinburgh and undertook Consultant posts at Wythenshawe Hospital, Manchester (2001-2007) and the John Radcliffe Hospital, Oxford (2007-2015).

He is a national and international key opinion leader and in frequent demand as a lecturer and speaker. He has been Honorary Secretary of the British Cardiovascular and Cardiovascular Intervention Societies, and Chairman of the European Society of Cardiology Working Group on Valvular Heart Disease. Research interests, which are delivered via collaborative links between London and Oxford, focus on the epidemiology and interventional treatment of valvular heart disease.

Professor Prendergast is Principal Course Director of PCR London Valves, the world’s largest meeting dedicated to transcatheter valve intervention, attracting a global faculty and over 3000 international delegates.  He is also a senior member of the PCR Board, the world’s largest educational programme in Interventional Cardiology, with an annual flagship meeting in Paris (12,000 delegates) and satellite meetings in Africa, Asia and the Gulf.  He lectures regularly in the UK and abroad, and contributes plenary lectures at the world’s leading cardiovascular conferences each year.

 

RESEARCH ACTIVITY

Over 250 original articles (>12,000 citations, h-index 35) and book chapters, including high impact leading articles in The New England Journal of Medicine, Circulation, Lancet, European Heart Journal and BMJ.

CURRENT ACTIVITY

A wide portfolio of studies exploring early clinical experience with innovative transcatheter valve technology.  Current projects include:

  • Edwards S3 Ultra Valve: First in Europe implantation.CE mark trial of 4thgeneration TAVI device
  • VITALE study: One of only 4 centres in Europe.CE mark trial investigating novel self-expanding TAVI device
  • Boston i-Sleeve. First in Europe experience with novel vascular sheath

Invasive coronary physiology in patients with low flow aortic stenosis pre- and post-TAVI (in conjunction with the British Heart Foundation)

Publications 2018/2019

  1. BINDER RK, DWECK M, PRENDERGAST B.  The Year in Cardiology 2019: Valvular Heart Disease.  Eur Heart J 2020 (In Press).
  2. ALLEN C, PATTERSON T, REDWOOD S, PRENDERGAST B.  Frailty in patients undergoing TAVR: frequently measured, seldom managed.  JACC Cardiovasc Intervention 2020 (In Press).
  3. BARBANTI M, WEBB JG, DVIR D, PRENDERGAST B.  Residual challenges in TAVI: moving forward.  Eurointervention 2019;15:857-866.
  4. TAMBURINO C, PIAZZA N, BAUMBACH, WINDECKER, MAISANO F, PRENDERGAST B.  2019 – a leap year for valvular heart disease.  Eurointervention 2019;15:821-823.
  5. ADAMS HSL, PRENDERGAST B, REDWOOD S. BIOVALVE: A new self-expanding supra-annular TAVR system.  JACC Cardiovasc Interv2019;Oct 11. pii: S1936-8798(19)31888-6. doi: 10.1016/ j.jcin.2019.09.002.
  6. COSTAG, DE BACKERO, PILGRIMT, KASELM, REDWOODS, AMINIANA, LANZJ, MICHELJ, PATTERSONT, WINDECKERS, PRENDERGAST B,GREENBAUM AB, SØNDERGAARD L.  Initial European experience with transcaval transcatheter aortic valve implantation.  Eurointervention 2019 Oct 29. pii: EIJ-D-19-00797. doi: 10.4244/EIJ-D-19-00797.
  7. SAITO Y, NAZIF T, BAUMBACH A, TCHETCHE D, LATIB A, KAPLE R, FORREST J, PRENDERGAST B, LANSKY A.  Adjunctive antithrombotic therapy for patients with aortic stenosis undergoing transcatheter aortic valve replacement.  JAMA Cardiology2019Nov 13. doi: 10.1001/jamacardio.2019.4367.
  8. IANNOPOLLO G, ROMANO V, BUZZATTI N, DE BACKER O, SØNDERGAARD L, MERKELY B, PRENDERGAST BD, GIANNINI F, COLOMBO A, LATIB A, GRANADA JF, CHIEFFO A, MONTORFANO M. A novel supra-annular plane that predicts TAVI prosthesis anchoring in raphe-type bicuspid aortic valve disease: the LIRA plane. EuroIntervention 2019 Oct 29. pii: EIJ-D-19-00951. doi: 10.4244/EIJ-D-19-00951.
  9. BUZZATTI N, ROMANO V, DE BACKER O, SOENDERGAARD L, ROSSEEL L, MAUROVICH-HORVAT P,KARADY J, MERKELY B, RUGGERI S, 
PRENDERGAST B, DE BONIS M, COLOMBO A, MONTORFANO M, 
LATIB A. Coronary access after repeated transcatheter aortic valve implantation: a glimpse into the future.  JACC Imaging 2019 (In Press).
  10. SCARSINI R, DE MARIA GL, JOSEPH J, FAN L, CAHILL T, KOTRONIAS, BURZOTTA F, NEWTON JD, KHARBANDA R, PRENDERGAST B, RIBICHINI F, BANNING AP.  Impact of complications during transfemoral transcatheter aortic valve replacement: How can they be avoided and managed? JAHA2019 Sep 17;8(18):e013801. doi: 10.1161/JAHA.119.013801.
  11. IUNG B, DELGADO V, ROSENHEK R, PRICE S, PRENDERGAST B, WENDLER O, DE BONIS M, TRIBOUILLOY C, EVANGELISTA A, BOGACHEV-PROKOPHIEV A, APOR A, INCE H, POPESCU B, PIERARD L, HAUDE M, HINDRICKS G, RUSCHITZKA F, WINDECKER S, BAX J, MAGGIONI A, VAHANIAN A, on behalf of the EORP VHD II Registry Investigators.  Contemporary presentation and management of valvular heart disease in Europe: The EURObservational Research Programme Valvular Heart Disease II Registry.  Circulation 2019;140:1156-1169.
  12. LANZ J, KIM W-K,WALTHER T,BURGDORF C, HELGE MÖLLMANN H, LINKE A,REDWOOD S, THILO C, HILKER M, JONER M, THIELE H, CONZELMANN L, CONRADI L, KERBER S, SCHYMIK G, PRENDERGAST B, HUSSER O, HEG D, JÜNI P, WINDECKER S, PILGRIM T, for the SCOPE I investigators.  Safety and efficacy of a self-expanding compared to a balloon-expandable bioprosthesis for transcatheter aortic valve replacement in patients with severe aortic stenosis.  Lancet 2019;394:1619-1628.
  13. HABIB G, ERBA P, IUNG B, DONAL E, COSYNS B, LAROCHE C, POPESCU BA, PRENDERGAST B, TORNOS P, SADEGHPOUR A, OLIVER L, VASKELYTE J-J, SOW R, AXLER O, MAGGIONI A, LANCELLOTTI P. Clinical Presentation, Aetiology and Outcome of Infective Endocarditis Results of the ESC-EORP EURO-ENDO (European Infective Endocarditis) registry: A Prospective Cohort Study.  Eur Heart J 2019;40:3222-3232.
  14. MODINE T, PRENDERGAST B, PIAZZA N, OVERTCHOUK P. Mitral valve regurgitation: a plea for transcatheter mitral valve replacement.  EuroIntervention 2019;15:567-570.
  15. CAHILL TJ, JEWELL PD, DENNE L, FRANKLIN RC, FRIGIOLA A, ORCHARD E, PRENDERGAST BD.  Contemporary epidemiology of infective endocarditis in patients with congenital heart disease: a UK prospective study.  Am Heart J 2019;215:70-77.
  16. BALDEEP S, SIDHU BS, GOULD J, SIENIEWICZB, PORTER B,PRENDERGAST B, REDWOOD S, RINALDI AC.  Successful percutaneous femoral extraction of a detached tricuspid valve‐in‐valve balloon delivery system. Clin Case Rep 2019;7:1577-1581.
  17. ADAMS H, PATTERSON, REDWOOD S, PRENDERGAST B.  Prior preparation prevents poor TAVR performance. JACC Interv 2019;12:1778-1780.
  18. PRENDERGAST B, REDWOOD S.  Transcatheter aortic valve replacement: a new gold standard for the treatment of aortic stenosis.  Circulation 2019;139:2724-2727.
  19. PATTERSON T, ADAMS H, ALLEN C, RAJANI R, PRENDERGAST B, REDWOOD S.  Indirect annuloplasty to treat functional mitral regurgitation: current results and future perspectives.  Frontiers in Cardiovascular Medicine 2019;6:60.doi: 10.3389/fcvm
  20. REDWOOD S, ALLEN C, PRENDERGAST B. TAVR in nonagenarians: age may be a fatal illness.  JACC Cardiovasc Interv 2019;12:921-922.
  21. MIGLIARO S, TRANI C, VERGALLO R, BUCCIMAZZA G, AURIGEMMA C, CHANNON K, BURZOTTA F, D’AMARIO D, CREA F, KHARBANDA R, BANNING A, PRENDERGAST B, LEONE AM, ANNIBALI GM, NICCOLI GP, DE MARIA GL, GALLI M, PORTO I. Dual quantitative coronary angiography accurately quantifies intracoronary thrombotic burden in patients with acute coronary syndrome: comparison with optical coherence tomography imaging.  Int J Cardiol 2019;292:25-31.
  22. OVERTCHOUK P,PRENDERGAST B, MODINET.  Why should we extend transcatheter aortic valve implantation to low-risk patients? A comprehensive review. Arch Cardiovasc Dis 2019;112:354-362.
  23. SIONTIS GCM, OVERTCHOUK P, CAHILL TJ, MODINE T,PRENDERGAST B, PRAZ F, PILGRIM T, PETRINIC T, NIKOLAKOPOULOU A, SALANTI G, SONDERGAARD L, VERMA S, JÜNI P, WINDECKER S.  Transcatheter aortic valve implantation versus surgical aortic valve replacement for treatment of symptomatic severe aortic stenosis: an updated meta-analysis. Eur Heart J 2019;40:3143-3153.
  24. PRAZ F, GRASSO C, TARAMASSO M, BAUMBACH A, PIAZZA N, TAMBURINO T, WINDECKER S, MAISANO F,PRENDERGAST B.  Mitral regurgitation in heart failure – time for a rethink.  Eur Heart J 2019;40:2189-2193.
  25. HABIB G, PATRIZIO LANCELLOTTI P, ERBA P-A, SADEGHPOUR A, MESHAAL M, SAMBOLA A, FURNAZ S, CITRO R, TERNACLE J, DONAL E, COSYNS B, POPESCU B, IUNG B, PRENDERGAST B,LAROCHE C, TORNOS P, PAZDERNIK M, MAGGIONI A, GALE CP, on behalf of the EURO-ENDO Investigators.  The ESC-EORP EURO-ENDO (European Infective Endocarditis) registry.  Eur Heart J Care Quality and Clinical Outcomes 2019;5:202-207.
  26. BOURANTAS CV, MODOLO R, BAUMBACH A, SØNDERGAARD L,PRENDERGAST B, OZKOR M, KENNON S, MATHUR A, MULLEN MJ, SERRUYS PW. The evolution of device technology in transcatheter aortic valve implantation.  EuroIntervention 2019;14:e1826-e1833.
  27. McCONKEY HZR, MARBER M, CHIRIBIRI A, PIBAROT P, REDWOOD SR, PRENDERGAST B.  The coronary microcirculation in aortic stenosis.  Circ Cardiovasc Int 2019;12:e007547.
  28. PATTERSON T, WITBERG G, REDWOOD S, PRENDERGAST B.  Balloon valve fracture at the time of valve-in-valve transcatheter aortic valve replacement.  Ex vivo modeling and clinical implications.  JACC Cardiovasc Int 2019;12:76-77.
  29. WITBERG G, PATTERSON T, REDWOOD S, PRENDERGAST B.  Future Directions. Transcatheter aortic valve implantation for low-risk patients: inevitable evolution or a step too far?  Rev Esp Cardiol 2019;72:664-671.
  30. LIMERES J, LIP GYH, DEL BLANCO BG, FERREIRA-GONZÁLEZ I, MUTUBERRIA M, ALFONSO F, BUENO H, CEQUIER A, PRENDERGAST B, ZUECO J, RODRÍGUEZ-LEOR O, BARRABÉS JA, GARCÍA-DORADO D, SAMBOLA A. Safety of drug-eluting stents compared to bare metal stents in patients with an indication for long-term oral anticoagulation: A propensity score matched analysis.  Thromb Res 2019;177:180-186.
  31. DE JAEGERE P, ROCATELLO G, PRENDERGAST BD, DE BACKER O, VAN MIEGHEM NM, RAJANI R.  Patient-specific computer simulation for transcatheter cardiac interventions: what a clinician needs to know.  Heart 2019;105(Suppl 2):s21-s27.
  32. VECCHI A, NIEDERER S, RAJANI R, REDWOOD S, PRENDERGAST B.  Minimally invasive transcatheter technology for heart valve disease.  In: Health 2040 – Better Health Within Reach. Annual Report of the Chief Medical Officer. Available at www.gov.uk.
  33. URSI M-P, DURANTE-MANGONI E, RAJANI R, HANCOCK J, CHAMBERS JB, PRENDERGAST B.  Infective endocarditis in the elderly: diagnostic and treatment options.  Drugs & Aging 2019;36:115-124.
  34. DE VECCHI A, NIEDERER S, RAJANI R, REDWOOD S, PRENDERGAST B. Individual patient-specific planning of minimally invasive transcatheter intervention for heart valve disease.  EClinicalMedicine 2019;6:9-10.
  35. McCONKEY H, PRENDERGAST B. Timing and mode of intervention for patients with valvular heart disease: an individualized approach.  Precision Clin Med 2018 (In Press).
  36. PATTERSON T, PRENDERGAST BD,REDWOOD S.  PCI and TAVI: who, why and when?  Eurointervention 2018;14:e1160-e1162.
  37. SERBAN RC, REDWOOD S, PRENDERGAST BD,RAJANI R.  Real time image integration for transcatheter mitral valve replacement in mitral annular calcification. J Thorac Cardiovasc Surg 2019;157:e135-e139.
  38. PRENDERGAST BD,BAUMGARTNER H, DELGADO V,GÉRARD O,HAUDE M,HIMMELMANN A, IUNG B,LEAFSTEDT M,LENNARTZ J,MAISANO F,MARINELLI EA,MODINE T,MUELLER M,REDWOOD S,RÖRICK O,SAHYOUN C,SAILLANT E,SØNDERGAARD L,THOENES M,THOMITZEK K,TSCHERNICH M,VAHANIAN A,WENDLER O,ZEMKE EJ,BAX. JJ.  Transcatheter Heart Valve Interventions:  Where are we?  Where are we going?  Eur Heart J 2019;40:422-440.
  39. GARDEZI S, MYERSON S, PRENDERGAST B.  Cardiac auscultation poorly predicts the presence of valvular heart disease in asymptomatic primary care patients.  Heart 2018;104:1832-1835.
  40. YOON SH, WHISENANT BK, BLEIZIFFER S, DELGADO V, DHOBLE A, SCHOFER N, ESCHENBACH L, BANSAL E, MURDOCH DJ, ANCONA M, SCHMIDT T, YZEIRAJ E, VINCENT F, NIIKURA H, KIM WK, ASAMI M, UNBEHAUN A, HIRJI S, FUJITA B, SILASCHI M, TANG GHL, KUWATA S, WONG SC, FRANGIEH AH, BARKER CM, DAVIES JE, LAUTEN A, DEUSCHL F, NOMBELA-FRANCO L, RAMPAT R, NICZ PFG, MASSON JB, WIJEYSUNDERA HC, SIEVERT H, BLACKMAN DJ, GUTIERREZ-IBANES E, SUGIYAMA D, CHAKRAVARTY T, HILDICK-SMITH D, DE BRITO FS JR, JENSEN C, JUNG C, SMALLING RW, ARNOLD M, REDWOOD S, KASEL AM, MAISANO F, TREEDE H, ENSMINGER SM, KAR S, KANEKO T, PILGRIM T, SORAJJA P, VAN BELLE E, PRENDERGAST BD, BAPAT V, MODINE T, SCHOFER J, FRERKER C, KEMPFERT J, ATTIZZANI GF, LATIB A, SCHAEFER U, WEBB JG, BAX JJ, MAKKAR RR.  Outcomes of TMVR for degenerated bioprostheses, failed annuloplasty rings and mitral annular calcification.  Eur Heart J 2019;40:441-451.
  41. PRENDERGAST B,BADDOUR L.  Risk of infective endocarditis due to invasive dental procedures: a NICE conclusion. Circulation2018;138:364-366.
  42. CAHILL TJ, CHEN M, HAYASHIDA K, LATIB A, MODINE T, PIAZZA N, REDWOOD S, SØNDERGAARDL, PRENDERGAST BD. TAVI – current status and future perspectives. Eur Heart J 2018;39:2625-2634.
  43. PRENDERGAST BD, McCONKEY HZR. Patient-prosthesis mismatch after aortic valve intervention – another win for TAVI. JACC Intervention 2018;11:781-783.
  44. BANKS T, RAZEGHI O, NTALAS I, AZIZ A, BEHAR JM, PRESTON R, CAMPBELL B, REDWOOD S, PRENDERGAST B, NIEDERER S, RAJANI R.  Automated quantification of mitral valve geometry on multi-slice computed tomography in patients with dilated cardiomyopathy – implications for transcatheter mitral valve replacement.  J Cardiovasc Comput Tomogr 2018;12:329-337.
  45. CAHILL TJ, PRENDERGAST BD.  Risk of infective endocarditis after left-sided surgical valve replacement.  Eur Heart J 2018;39:2676-2678.
  46. PAWADE T, CLAVEL M-A, TROBOUILLOY C, DREYFUS J, MATHIEU T, TASTET L, RENARD C, GUN M, JENKINS WSA, MACRON L, SECHRIST JW, LACOMIS JM, NGUYEN V, GAY LG, CALABRIA HC, NTALAS I, CARTLIDGE TRG, PRENDERGAST B, RAJANI R, EVANGELISTA A, CAVALCANTE JL, NEWBY DE, PIBAROT P, MESSIKA-ZEITOUN D, DWECK M.  Computed Tomography Aortic Valve Calcium Scoring in Patients with Aortic Stenosis.  Circ Cardiovasc Imaging 2018;11:e007146.
  47. HARDING DE, PRENDERGAST B.  Advanced imaging improves the diagnosis of infective endocarditis.  F1000 2018 (In Press).
  48. KARADY J, NTALAS I, PRENDERGAST B, BLAUTH C, NIEDERER S, MAOROVICH-HORVAT P, RAJANI R.  Transcatheter mitral valve replacement in mitral annulus calcification – the art of computer simulation.  Journal of Cardiovascular Computed Tomography 2018;12:153-157.
  49. YOON SH, SCHMIDT T, BLEIZIFFER S, SCHOFER N, FIORINA C, MUNOZ-GARCIA AJ, YZEIRAJ E, AMAT-SANTOS IJ, TCHETCHE D, JUNG C, FUJITA B, MANGIERI A, DEUTSCH MA, UBBEN T, DEUSCHL F, KUWATA S, DE BIASE C, WILLIAMS T, DHOBLE A, KIM WK, FERRARI E, BARBANTI M, VOLLEMA EM, MICELI A, GIANNINI C, ATTIZZANI GF, KONG WKF, GUTIERREZ-IBANES E, JIMENEZ DIAZ VA, WIJEYSUNDERA HC, KANEKO H, CHAKRAVARTY T, MAKAR M, SIEVERT H, HENGSTENBERG C, PRENDERGAST BD,VINCENT F, ABDEL-WAHAB M, NOMBELA-FRANCO L, SILASCHI M, TARANTINI G, BUTTER C, ENSMINGER SM, HILDICK-SMITH D, PETRONIO AS, YIN WH, DE MARCO F, TESTA L, VAN MIEGHEM NM, WHISENANT BK, KUCK KH, COLOMBO A, KAR S, MORIS C, DELGADO V, MAISANO F, NIETLISPACH F, MACK MJ, SCHOFER J, SCHAEFER U, BAX JJ, FRERKER C, LATIB A, MAKKAR RR.   Transcatheter Aortic Valve Replacement in Pure Native Aortic Valve Regurgitation. J Am Coll Cardiol 2017;70:2752-2763.
  50. PAGNESI M, REGAZZOLI D,ANCONA MB,MANGIERI A, LANZILLO G, GIANNINI F,BUZZATTI N, PRENDERGAST B, KODALI S, LANSKY AJ, COLOMBO A, LATIB A. Cerebral Embolic Risk during Transcatheter Mitral Valve Interventions: An Unaddressed and Unmet Clinical Need?JACC Intervention2018;11:517-528.
  51. THORNHILL MH, JONES S, PRENDERGAST B, BADDOUR LM, CHAMBERS JB, LOCKHART PB, DAYER MJ. Quantifying infective endocarditis risk in patients with predisposing cardiac conditions.  Eur Heart J 2018;39:586-595.
  52. McCONKEY H, RAJANI R, PRENDERGAST BD.  Improving outcomes in chronic aortic regurgitation: timely diagnosis, access to specialist assessment and earlier surgery. Heart 2018;104:794-795.